Document Type
Review
Subject Areas
Oral Biology
Keywords
Gene mutations; Dentinogenesis; DSPP; DMP1; Dentinogenesis imperfecta; Gene therapy
Abstract
Writing a comprehensive review on gene mutations affecting dentin mineralization requires thorough research and organization, as each section examines how specific mutations influence this process, supported by relevant findings. Mutations in genes such as DSPP, DMP1, andMEPE impair dentin structure and mineralization by disrupting odontoblast function, dentin matrix integrity, and mineral deposition. These genetic alterations interfere with key biological processes, including odontoblast differentiation and matrix formation, through altered signaling pathways such as Wnt/β- catenin and TGF-β, contributing to dental disorders like Dentinogenesis Imperfecta (DI). Gaining molecular insights into these disruptions enhances our understanding of dentin biology and supports early diagnosis, genetic counseling, and the development of emerging therapies, including gene therapy and stem cell-based regeneration. Understanding these mechanisms is therefore crucial for advancing both scientific knowledge and the clinical management of genetic dental disorders.
How to Cite This Article
Abdelfattah, Mohamed Yehia; Said, Yara Sameh; Elsaady, Shimaa A.; AbdallahAhmed, Shahenda A.; and Abou-Zeid, Wael
(2025)
"Genetic Mutations Affecting Dentin Formation: Molecular Insights and Therapeutic Strategies,"
Trends in advanced sciences and technology: Vol. 3, Article 2.
DOI: 10.62537/2974-444X.1045
Available at:
https://tast.researchcommons.org/journal/vol3/iss1/2
